Search Details

 


photo


Click here to return
to the previous page


Wendy H. Raskind MD, PhD

Professor
Professor, Department of Medicine

wendyrun@u.washington.edu
Phone: (206) 543-3177
Fax: (206) 616-7366

Site: UW Medical Center
Medical Genetics

Link to CV

Division
Psychiatric Neurosciences
Link to Website


Board Certification
American Board of Internal Medicine

Bio

The focus of research in the Raskind laboratory is the genetics of neurodegenerative and neurobehavioral disorders, both single gene and complex in etiology. Raskind and colleagues investigate a variety of neurogenetic disorders. Using linkage analysis and positional cloning, the lab identified the genes for multiple disorders, including X-linked sideroblastic anemia and ataxia and autosomal dominant spinocerebellar ataxia type14. They are now combining linkage information with “next generation” techniques of exome resequencing and bioinformatics for disease gene discovery. Recent discoveries include the genes for a dominant myokymia/choreiform disorder and an X-linked parkinsonian syndrome. They are studying the biochemical and cellular effects of the mutations in vitro and in model organisms.

A second main area of interest is the genetic basis of common and complex disorders. To identify genes that contribute to dyslexia, they utilize an extensive dataset collected from nuclear and extended families of children with reading impairment, and study endophenotypes based on performance on clinical assessment tests that evaluate reading, writing, and spelling ability, and executive function. These traits are analyzed by quantitative trait segregation and linkage methods. To identify genes that contribute to familial late onset Alzheimer’s Disease, the group is applying next generation sequencing techniques and identity-by-descent linkage analyses in individual multiplex pedigrees.







Grand Rounds   |   Faculty Employment   |   Staff Employment   |   Fellows Employment   |   Contact Us   |   Site Map   |   Department Intranet   |   UW Home