Bio
I direct the Molecular Neurosciences laboratory in the recently opened Harborview Research and Training Building.
I am studying the regulation of serotonin receptors in rat brain in animal models of psychiatric illnesses. There are currently three main projects in the laboratory:
1. The regulation of 5-HT1B receptors and mRNA by antidepressants and in animal models of depression. We have found that 5-HT1B receptor mRNA is increased in the dorsal raphe nucleus of learned helpless rats and is reduced by serotonin-selective reuptake inhibitors. We are exploring how these medications specifically regulate presynaptic 5-HT1B receptors using molecular pharmacological and physiological approaches.
2. The signal transduction pathways mediating 5-HT1B action in rat brain and in cell lines.
3. Regulation of 5-HT6 and 5-HT7 receptors by antipsychotic drugs.
Our currently used techniques include: viral mediated gene transfer; in situ hybridization; RT-PCR, radioligand binding; immunocytochemistry; stereotaxic surgery; drug administration, in vitro cell culture, and signal transduction reporter gene assays.
These research projects are currently supported by the NIMH, the National Alliance for Research in Schizophrenia and Depression, the Stanley Foundation, Lilly Research Laboratories, and the Royalty Research Fund.
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